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Human IGFBP-1, native protein
Insulin-like Growth Factor Binding Protein-1, human Synonyms: Igf binding protein-1, 34 k IGFBP, PP12, Placental protein-12, AFBP, Amniotic fluid binding protein, Alpha-pregnancy-associated endometrial globulin, Growth hormone independent binding protein, Binding protein-28, Binding protein-26, Binding protein-25, Ibp1,
Product Specifications Human IGFBP-1:
Native human Insulin-like Growth Factor Binding Protein-1 (IGFBP-1) is a 218 amino acid protein that is a member of a family of six circulating proteins which bind Insulin-like Growth Factors (IGF-I and IGF-II) with high affinity and modulate their metabolic and mitogenic effects. Native human IGFBP-1 is produced by the liver, ovarian granulosa cells and decidualised endometrium and a number of other cell types. IGFBP-1 binds both IGF-I and IGF-II. Serum IGFBP-1 levels are regulated by insulin-induced inhibition of IGFBP-1 production. IGFBP-1 appears to inhibit smooth muscle migration in response to IGF-I or IGF-II and to stimulate wound healing in response to IGF-II.
References:
Liu et al (1991) Biochem. Biophys. Res. Comm. 174, 673-679.
Schuller et al (1993) Growth Regulation 3, 32-34.
Source: Purified from human amniotic fluid of individuals that have been shown by certified tests to be negative for hepatitis.
Purity: > 95% (as determined by FPLC and SDS-PAGE) Consists of 3-4 phosphorylated forms.
Molecular weight: 25.3 kDa
Appearance: Lyophilized white powder
Biological Activity: Native human IGFBP-1 binds both IGF-I and IGF-II. Inhibition of serum-induced stimulation of DNA synthesis in chick embryo fibroblast primary cultures - IC50 (1% serum) ~ 300 ng/ml Inhibition of IGF-I stimulated proliferation of NUC-1 cells - IC50 ~100
Storage/Stability: At least 2 years at 2-4°C (lyophilized).
This is a GroPep specification. ibt is authorized distributor of GroPep.
Rev2013-03
Datasheet for Human IGFBP-1, native protein